Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7974622 | 0.88 | CYSLTR2 (0.47) | CYSLTR2CYSLTR1CYP2C9CYP1A2MAPT | |
| SCHEMBL9176938 | 0.83 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL9180066 | 0.80 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL9179085 | 0.80 | MAPT (0.43) | CYSLTR2CYSLTR1ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL2009246 | 0.75 | ALDH1A1 (0.53) | CYSLTR2CYSLTR1ALDH1A1CYP2C9CYP1A2 | |
| SCHEMBL6683046 | 0.72 | SELL (0.47) | ALDH1A1CYP1A2MAPTKDM4EPOLB | |
| SCHEMBL9175493 | 0.71 | HTT (0.40) | CYSLTR2CYSLTR1ALDH1A1MAPTTHRB | |
| SCHEMBL288795 | 0.70 | ERN1 (0.40) | CYSLTR2CYSLTR1ALDH1A1HSD17B1CTSD | |
| SCHEMBL9178362 | 0.70 | CTSD (0.46) | CYSLTR2CYSLTR1ALDH1A1CTSDMEN1 | |
| SCHEMBL28124605 | 0.69 | ALDH1A1 (0.48) | ALDH1A1CYP2C9CYP1A2CYP2D6CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5393768-A | Treating hypersensitivity reactions such as asthma | ELI LILLY AND COMPANY (US) | 1995-02-28 | — | — | US | disclosed |
| US-5105017-A | Antiallergens | ELI LILLY AND COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0132366-B1 | LEUKOTRIENE ANTAGONISTS | ELI LILLY AND COMPANY (US) | 1990-01-03 | — | — | EP | disclosed |
| EP-0132366-A2 | Leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1985-01-30 | — | — | EP | disclosed |