Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7802020 | 0.95 | MEN1 (0.46) | MEN1KMT2AHSD11B1ALDH1A1TSHR | |
| SCHEMBL9178311 | 0.92 | L3MBTL1 (0.46) | MEN1KMT2AALDH1A1KDM4ETP53 | |
| SCHEMBL7797652 | 0.86 | L3MBTL1 (0.46) | MEN1KMT2AALDH1A1KDM4ETP53 | |
| SCHEMBL8654336 | 0.83 | ALDH1A1 (0.45) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL9178546 | 0.81 | SMN1; SMN2 (0.45) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL7791495 | 0.80 | NPC1 (0.46) | MEN1KMT2AALDH1A1KDM4ETP53 | |
| SCHEMBL7801959 | 0.77 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1HSD17B10HPGD | |
| SCHEMBL7797567 | 0.77 | ALDH1A1 (0.47) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL7791499 | 0.76 | CNR2 (0.41) | MEN1KMT2AALDH1A1TSHRKDM4E | |
| SCHEMBL8656066 | 0.76 | ALDH1A1 (0.46) | MEN1KMT2AALDH1A1TSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662948-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-07-19 | — | — | EP | disclosed |
| WO-1995003271-A1 | 2-AMINO-4-PHENYL-4-OXO-BUTYRIC ACID DERIVATIVES WITH KYNURENINASE AND/OR KYNURENINE-3-HYDROXYLASE INHIBITING ACTIVITY | PHARMACIA S.P.A. (IT) | 1995-02-02 | — | — | WO | disclosed |