Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4D | Q6B0I6 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 1/20 | 0.44 |
| ▸ | SKP1 | P63208 | 1/20 | 0.44 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.42 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.42 |
| ▸ | BTK | Q06187 | 1/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 3/20 | 0.41 |
| ▸ | DRD3 | P35462 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9181605 | 0.92 | KDM4E (0.47) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL9183057 | 0.86 | CKS1B (0.41) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL27643795 | 0.86 | KDM4E (0.50) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL9183089 | 0.85 | SLC9A1 (0.53) | — | |
| SCHEMBL9177609 | 0.85 | DRD2 (0.48) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL9183298 | 0.84 | NPC1 (0.49) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL9259719 | 0.84 | CKS1B (0.41) | KDM4DCKS1BSKP1SKP2NAMPT | |
| SCHEMBL14334990 | 0.83 | KDM4E (0.67) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL38659211 | 0.83 | KDM4E (0.49) | KDM4DKDM4ENPC1ALDH1A1MAPT | |
| SCHEMBL9180254 | 0.82 | NR1H2 (0.47) | CKS1BSKP1SKP2OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5461066-A | 4-amino-1-piperidylbenzoylguanidines | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1995-10-24 | — | — | US | disclosed |