SCHEMBL9178772

SCHEMBL9178772

CC1(C2(c3ccc(C(N)=O)cc3)OCCO2)CC1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXRA P19793 4/20 0.40
RXRB P28702 3/20 0.40
CYP26A1 O43174 2/20 0.40
CYP26B1 Q9NR63 2/20 0.40
NOS1 P29475 1/20 0.40
RXRG P48443 1/20 0.38
PARP10 Q53GL7 5/20 0.38
PARP4 Q9UKK3 2/20 0.38
PARP1 P09874 2/20 0.38
CA2 P00918 2/20 0.38
CA1 P00915 1/20 0.38
PARP2 Q9UGN5 1/20 0.38
TSHR P16473 3/20 0.38
ALDH1A1 P00352 1/20 0.36
KMT2A Q03164 1/20 0.36
PARP15 Q460N3 1/20 0.36
PARP14 Q460N5 1/20 0.36
PARP16 Q8N5Y8 1/20 0.36
PARP11 Q9NR21 1/20 0.36
CHEK2 O96017 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9182861 0.87 RXRA (0.52) RXRARXRBCYP26A1CYP26B1RXRG
SCHEMBL1702560 0.74 PARP10 (0.45) NOS1PARP10PARP4PARP1CA2
SCHEMBL9180083 0.73 NOS1 (0.40) RXRARXRBCYP26A1CYP26B1NOS1
SCHEMBL615636 0.72 PARP10 (0.38) NOS1PARP10PARP4PARP1CA2
SCHEMBL9178779 0.71 KDM4E (0.38) PARP1PARP2TSHRALDH1A1MAPT
SCHEMBL13351657 0.70 PARP10 (0.46) NOS1PARP10PARP4PARP1CA2
SCHEMBL9184857 0.69 PARP10 (0.38) NOS1PARP10PARP4PARP1CA2
SCHEMBL5297495 0.69 PARP10 (0.45) NOS1PARP10PARP4PARP1CA2
SCHEMBL14744167 0.68 PARP1 (0.44) NOS1PARP10PARP4PARP1CA2
SCHEMBL27317069 0.67 PARP10 (0.43) NOS1PARP10PARP4PARP1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5378728-A Benzoic acid derivatives as antidiabetic agents SANDOZ LTD. (CH) 1995-01-03 US claimed
US-5378728-A Benzoic acid derivatives as antidiabetic agents SANDOZ LTD. (CH) 1995-01-03 US disclosed