Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9467135 | 0.91 | HTR1A (0.51) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9183299 | 0.86 | HTR1A (0.58) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9467285 | 0.85 | HTR1A (0.41) | HTR1A | |
| SCHEMBL9467283 | 0.85 | HTR1A (0.41) | HTR1A | |
| SCHEMBL9466855 | 0.85 | HTR1A (0.45) | HTR1A | |
| SCHEMBL9181634 | 0.85 | HTR1A (0.53) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL9466374 | 0.83 | HTR1A (0.51) | HTR1AALDH1A1LMNACYP3A4ALOX12 | |
| SCHEMBL1037297 | 0.82 | — | — | |
| SCHEMBL9183269 | 0.81 | POLB (0.39) | LMNA | |
| SCHEMBL9176472 | 0.80 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |