Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.46 |
| ▸ | MDM4 | O15151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | GALK1 | P51570 | 1/20 | 0.42 |
| ▸ | CCR6 | P51684 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185269 | 1.00 | MAPT (0.51) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL29940752 | 0.90 | MAPT (0.47) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL3293089 | 0.90 | MAPT (0.49) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL3293086 | 0.90 | MAPT (0.49) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL1137907 | 0.87 | MEN1 (0.49) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL11814908 | 0.86 | MAPT (0.51) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL1070286 | 0.84 | MEN1 (0.53) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL14186862 | 0.84 | MAPT (0.53) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL2205707 | 0.82 | MAPT (0.51) | MAPTKMT2AMEN1NPC1ALDH1A1 | |
| SCHEMBL5078615 | 0.82 | MAPT (0.51) | MAPTKMT2AMEN1NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5447937-A | CNS active tetrahydrobenzothienopyridines | SMITHKLINE BEECHAM P.L.C. (GB) | 1995-09-05 | — | — | US | disclosed |
| EP-0612323-A1 | CNS ACTIVE TETRAHYDROBENZOTHIENOPYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1994-08-31 | — | — | EP | disclosed |
| EP-0597966-A1 | CNS ACTIVE TETRAHYDROBENZOTHIENOPYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1994-05-25 | — | — | EP | disclosed |
| EP-0327223-B1 | ANXIOLYTIC AND ANTIDEPRESSANT TETRAHYDROBENZOTHIENOPYRIDINE DERIVATIVES | BEECHAM GROUP PLC (GB) | 1993-06-02 | — | — | EP | disclosed |
| WO-1993009122-A1 | CNS ACTIVE TETRAHYDROBENZOTHIENOPYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1993-05-13 | — | — | WO | disclosed |
| WO-1993004068-A1 | CNS ACTIVE TETRAHYDROBENZOTHIENOPYRIDINES | SMITHKLINE BEECHAM PLC (GB) | 1993-03-04 | — | — | WO | disclosed |
| US-5093493-A | Anxiolytic agents, antidepressants | BEECHAM GROUP P.L.C. (GB) | 1992-03-03 | — | — | US | disclosed |
| EP-0327223-A1 | Anxiolytic and antidepressant tetrahydrobenzothienopyridine derivatives | BEECHAM GROUP PLC (GB) | 1989-08-09 | — | — | EP | disclosed |