Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Mycophenolic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 known ✓ | P12268 | 20/20 | 0.98 |
| ▸ | IMPDH1 known ✓ | P20839 | 10/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.98 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.98 |
| ▸ | LMNA | P02545 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.98 |
| ▸ | HPGD | P15428 | 1/20 | 0.98 |
| ▸ | UGT2B7 | P16662 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.98 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.98 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.78 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.78 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Mycophenolic Acid SCHEMBL1374332 | 1.00 | IMPDH2 (0.98) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL1230249 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL29645054 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL5500098 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL1657813 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL2514376 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL4549 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL29380425 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL5259872 | 0.99 | IMPDH2 (1.00) | IMPDH2IMPDH1KDM4EALDH1A1LMNA | |
| Mycophenolic Acid SCHEMBL6502425 | 0.98 | IMPDH2 (0.98) | IMPDH2IMPDH1KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0670724-A1 | USE OF MYCOPHENOLIC ACID, MYCOPHENOLATE MOFETIL OR DERIVATE THEREOF TO INHIBIT STENOSIS | SYNTEX (U.S.A.) INC. (US) | 1995-09-13 | — | — | EP | disclosed |
| WO-1994012184-A1 | USE OF MYCOPHENOLIC ACID, MYCOPHENOLATE MOFETIL OR DERIVATE THEREOF TO INHIBIT STENOSIS | SYNTEX (U.S.A.) INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5177072-A | Treatment of autoimmune inflammatory, and psoriatic diseases with heterocyclic aminoalkyl esters of mycophenolic acid and derivatives | SYNTEX (U.S.A.) INC. (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0281713-B1 | MORPHOLINOETHYLESTER OF MYCOPHENOLIC ACID AND DERIVATIVES THEREOF, THEIR PREPARATION AND USE IN PHARMACEUTICAL COMPOSITIONS | SYNTEX (U.S.A.) INC. (US) | 1991-10-09 | — | — | EP | disclosed |
| US-4948793-A | Treatment of autoimmune diseases with the morpholinoethyl ester of mycophenolic acid, and derivatives thereof | SYNTEX (U.S.A.) INC. (US) | 1990-08-14 | — | — | US | disclosed |
| US-4868153-A | IMMUNOSUPPRESSION | SYNTEX (U.S.A.) INC. (US) | 1989-09-19 | — | — | US | disclosed |
| US-4861776-A | Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof, compositions and use | SYNTEX (U.S.A) INC. (US) | 1989-08-29 | — | — | US | disclosed |
| US-4808592-A | ANTIBODY INHIBITORS; ANTIINFLAMMATORY AGENTS | SYNTEX (U.S.A.) INC. (US) | 1989-02-28 | — | — | US | disclosed |
| US-4786637-A | IMMUNOSUPPRESSIVE AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-11-22 | — | — | US | disclosed |
| EP-0281713-A1 | Morpholinoethylester of mycophenolic acid and derivatives thereof, their preparation and use in pharmaceutical compositions | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4753935-A | ANTIBODY INHIBITORS; ANTITUMOR, ANTIINFLAMMATORY, ANTIVIRAL AND ANTIPSORIASIS AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-06-28 | — | — | US | disclosed |
| US-4748173-A | IMMUNOSUPRESSIVE, ANTIINFLAMMATORY, ANTITUMOR, ANTIVIRAL, AND ANTIPSORIASIS AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-05-31 | — | — | US | disclosed |
| US-4727069-A | ANTIBODY INHIBITORS, ANTIINFLAMMATORY, ANTITUMOR AGENTS, VIRICIDES, AND ANTIPSORIATIC AGENTS | SYNTEX (U.S.A.) INC. (US) | 1988-02-23 | — | — | US | disclosed |