Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 6/20 | 0.53 |
| ▸ | TUBB | P07437 | 6/20 | 0.53 |
| ▸ | TUBA3C | P0DPH7 | 6/20 | 0.53 |
| ▸ | TUBA1B | P68363 | 6/20 | 0.53 |
| ▸ | TUBA4A | P68366 | 6/20 | 0.53 |
| ▸ | TUBB4B | P68371 | 6/20 | 0.53 |
| ▸ | TUBB3 | Q13509 | 6/20 | 0.53 |
| ▸ | TUBB2A | Q13885 | 6/20 | 0.53 |
| ▸ | TUBB8 | Q3ZCM7 | 6/20 | 0.53 |
| ▸ | TUBA3E | Q6PEY2 | 6/20 | 0.53 |
| ▸ | TUBA1A | Q71U36 | 6/20 | 0.53 |
| ▸ | TUBA1C | Q9BQE3 | 6/20 | 0.53 |
| ▸ | TUBB6 | Q9BUF5 | 6/20 | 0.53 |
| ▸ | TUBB2B | Q9BVA1 | 6/20 | 0.53 |
| ▸ | TUBB1 | Q9H4B7 | 6/20 | 0.53 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.43 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 3/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9185981 | 0.89 | TUBB4A (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL19951523 | 0.83 | ALDH1A1 (0.61) | ESR1ESR2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL8697184 | 0.81 | TUBB4A (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27293617 | 0.79 | ESR2 (0.51) | ESR1ESR2CYP1A2CYP2C19CYP2D6 | |
| SCHEMBL3674989 | 0.79 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL9719915 | 0.78 | CCR1 (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL10910082 | 0.78 | PTGS2 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL29061980 | 0.78 | PTGS2 (0.47) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL28655367 | 0.78 | TUBB4A (0.57) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL23606201 | 0.77 | ESR2 (0.76) | ESR1ESR2CYP1A2CYP2C19CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430062-A | Combretastatin analogues; inhibition of tubulin polymerization and colchicine binding; antitumor,-mitotic and -neoplastic agents | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-07-04 | — | — | US | disclosed |
| EP-0641301-A1 | STILBENE DERIVATIVES AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1993023357-A1 | STILBENE DERIVATIVES AS ANTICANCER AGENTS | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1993-11-25 | — | — | WO | disclosed |