Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 6/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.50 |
| ▸ | PDE7B | Q9NP56 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.43 |
| ▸ | GSTM2 | P28161 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881808 | 0.86 | MAPT (0.58) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1713219 | 0.85 | PDE7A (0.65) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL30338244 | 0.85 | PDE7A (0.65) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL3384869 | 0.83 | PDE7A (0.58) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL7665295 | 0.83 | PDE7A (0.67) | PDE7ASMN1; SMN2PDE7BMEN1KMT2A | |
| SCHEMBL2614719 | 0.83 | PDE7A (0.59) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11760310 | 0.83 | PDE7A (0.56) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10923003 | 0.83 | PDE7A (0.65) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL25250134 | 0.82 | PDE7A (0.66) | PDE7ASMN1; SMN2PDE7BMAPTALDH1A1 | |
| SCHEMBL12925885 | 0.82 | PDE7A (0.51) | PDE7ASMN1; SMN2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0451675-B1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON SPA (IT) | 1995-11-02 | — | — | EP | disclosed |
| US-5191078-A | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.P.A. (IT) | 1993-03-02 | — | — | US | disclosed |
| US-5109134-A | PROCESS FOR THE DIRECT AND REGIOSELECTIVE FUNCTIONALIZATION IN POSITION 2 OF PHENOTHIAZINE | ZAMBON GROUP S.P.A. (IT) | 1992-04-28 | — | — | US | disclosed |
| US-5089613-A | Sulfonation of N-acylphenothiazine with sulfuric acid, oleum or chlorosulfonic acid then reduciton to mercaptan and S-alkylation | ZAMBON GROUP S.P.A. (IT) | 1992-02-18 | — | — | US | disclosed |
| EP-0451675-A1 | Process for the direct and regioselective functionalization in position 2 of phenothiazine | ZAMBON GROUP S.p.A. (IT) | 1991-10-16 | — | — | EP | disclosed |
| EP-0433841-A2 | Process for the direct and regioselective functionalization in position 2 of phenotiazine | ZAMBON GROUP S.p.A. (IT) | 1991-06-26 | — | — | EP | disclosed |