Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179426 | 0.85 | OPRM1 (0.46) | OPRM1SIGMAR1 | |
| SCHEMBL13548371 | 0.82 | OPRM1 (0.60) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL14001237 | 0.76 | OPRM1 (0.52) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL6007693 | 0.75 | SMN1; SMN2 (0.46) | SIGMAR1 | |
| SCHEMBL6007699 | 0.75 | SMN1; SMN2 (0.46) | SIGMAR1 | |
| SCHEMBL16926353 | 0.75 | OPRM1 (0.51) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL16915579 | 0.75 | OPRM1 (0.51) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL20473610 | 0.75 | OPRM1 (0.51) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL16926718 | 0.75 | OPRM1 (0.51) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 | |
| SCHEMBL16915737 | 0.75 | OPRM1 (0.51) | OPRM1SIGMAR1CYP3A4HSD17B10OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0413455-B1 | Azabicyclo quinolone carboxylic acids | PFIZER (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5391763-A | 3-aza-bicyclo[3.1.0]hexanes which are intermediates for anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1995-02-21 | — | — | US | disclosed |
| US-5266569-A | Azatricyclo carboxylic acids useful as anti-bacterial agents | PFIZER INC. (US) | 1993-11-30 | — | — | US | disclosed |
| US-5229396-A | Anti-bacterial azabicyclo quinolone carboxylic acids | PFIZER INC. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5164402-A | Bactericides | PFIZER INC (US) | 1992-11-17 | — | — | US | disclosed |