Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | F7 | P08709 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15300222 | 0.85 | PLAAT3 (0.48) | MEN1KMT2ATRPV1IDO1LMNA | |
| SCHEMBL4682902 | 0.82 | MEN1 (0.50) | SMN1; SMN2MEN1KMT2AALDH1A1HPGD | |
| SCHEMBL919132 | 0.82 | TSHR (0.57) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4681589 | 0.80 | KMT2A (0.46) | MEN1KMT2AALDH1A1F7IDO1 | |
| SCHEMBL10592708 | 0.79 | TSHR (0.54) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL9667299 | 0.76 | TSHR (0.51) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL11391340 | 0.76 | PLA2G1B (0.50) | KMT2AALDH1A1HPGDLMNAPOLB | |
| SCHEMBL13039326 | 0.75 | TSHR (0.54) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL14261637 | 0.75 | TSHR (0.54) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 | |
| SCHEMBL4019644 | 0.75 | TSHR (0.57) | TSHRSMN1; SMN2MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507317-B1 | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives | OTSUKA PHARMA CO LTD (JP) | 1997-01-15 | — | — | EP | claimed |
| EP-0507317-A2 | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-07 | — | — | EP | claimed |
| EP-2066623-B1 | PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF | OTSUKA PHARMA CO LTD (JP) | 2013-06-19 | — | — | EP | disclosed |
| US-7868207-B2 | Process for producing 1-(3,4-dichlorobenzyl)-5-octylbiguanide or a salt thereof | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2011-01-11 | — | — | US | disclosed |
| US-20090270653-A1 | PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2009-10-29 | — | — | US | disclosed |
| EP-2066623-A1 | PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF | Otsuka Pharmaceutical Co., Ltd. (JP) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008026757-A1 | PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2008-03-06 | — | — | WO | disclosed |
| EP-0507317-B1 | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives | OTSUKA PHARMA CO LTD (JP) | 1997-01-15 | — | — | EP | disclosed |
| EP-0507317-A2 | Biguanide derivatives, manufacturing method thereof, and disinfectants containing the derivatives | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1992-10-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090270653-A1 | PROCESS FOR PRODUCING 1-(3,4-DICHLOROBENZYL)-5-OCTYLBIGUANIDE OR A SALT THEREOF | SLC6A9, CA9, ALKBH1 | TSHR 4117/4885SMN1; SMN2 3937/4885MEN1 3812/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.