Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARA | P10276 | 12/20 | 0.50 |
| ▸ | RARB | P10826 | 11/20 | 0.45 |
| ▸ | RARG | P13631 | 10/20 | 0.45 |
| ▸ | RXRA | P19793 | 4/20 | 0.45 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.42 |
| ▸ | CYP26B1 | Q9NR63 | 3/20 | 0.40 |
| ▸ | CYP26A1 | O43174 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9184087 | 0.79 | RARB (0.61) | RARARARBRARGRXRACYP26B1 | |
| SCHEMBL9187990 | 0.79 | RARB (0.41) | RARARARBRARGRXRAABCB1 | |
| SCHEMBL9190381 | 0.77 | RARA (0.53) | RARARARBRARGRXRAABCB1 | |
| SCHEMBL7647113 | 0.76 | ABCB1 (0.69) | RARARARBRARGRXRAABCB1 | |
| SCHEMBL9521094 | 0.74 | RARB (0.58) | RARARARBRARGRXRACYP26B1 | |
| SCHEMBL9186798 | 0.73 | CYP3A4 (0.56) | RARARARBRARGRXRAABCB1 | |
| SCHEMBL9190385 | 0.69 | RARA (0.50) | RARARARBRARGRXRAABCB1 | |
| Etarotene SCHEMBL636235 | 0.68 | RARG (0.67) | RARARARBRARGRXRACYP26A1 | |
| Etarotene SCHEMBL7061143 | 0.68 | RARG (0.67) | RARARARBRARGRXRACYP26A1 | |
| Etarotene SCHEMBL10494236 | 0.68 | RARG (0.67) | RARARARBRARGRXRACYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5475017-A | Skin disorders, antitumor agents; side effect reduction | BASF AKTIENGESELLSCHAFT (DE) | 1995-12-12 | — | — | US | disclosed |
| US-5338749-A | Treating rheumatic or arthritic disorders | BASF AKTIENGESELLSCHAFT (DE) | 1994-08-16 | — | — | US | disclosed |
| US-5206242-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1993-04-27 | — | — | US | disclosed |
| US-5196532-A | Treatment of skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1993-03-23 | — | — | US | disclosed |
| US-5061705-A | Skin disorders | BASF AKTIENGESELLSCHAFT (DE) | 1991-10-29 | — | — | US | disclosed |