Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.50 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21985215 | 0.92 | ACHE (0.52) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL9192549 | 0.86 | ACHE (0.45) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL4383206 | 0.84 | CARM1 (0.58) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL4376306 | 0.82 | ACHE (0.56) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL13646385 | 0.82 | ACHE (0.56) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL4375693 | 0.80 | CARM1 (0.54) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL18772772 | 0.80 | CARM1 (0.48) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL4373255 | 0.79 | CARM1 (0.58) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL23895398 | 0.78 | ACHE (0.52) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL22550897 | 0.78 | ACHE (0.42) | ACHEHRH3CARM1PRMT6PRMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7521457-B2 | Pyrimidines as PLK inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-04-21 | — | — | US | disclosed |
| EP-0361791-B1 | Azacyclic derivatives useful as medicaments | SMITHKLINE BEECHAM FARMA (IT) | 1995-11-08 | — | — | EP | disclosed |
| EP-0361791-A2 | Azacyclic derivatives useful as medicaments | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |