Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.36 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.36 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.36 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13419789 | 0.89 | ACHE (0.43) | ACHEHRH3KDM4ECARM1PRMT6 | |
| SCHEMBL9192552 | 0.86 | ACHE (0.52) | ACHEHRH3CHRM5ADRA2CCARM1 | |
| SCHEMBL4633471 | 0.84 | KDM4E (0.53) | HRH3KDM4EL3MBTL1CYP3A4CYP2C19 | |
| SCHEMBL1640075 | 0.84 | KDM4E (0.53) | HRH3KDM4EL3MBTL1CYP3A4CYP2C19 | |
| SCHEMBL9370937 | 0.79 | HRH3 (0.48) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL21985215 | 0.78 | ACHE (0.52) | ACHEHRH3CARM1PRMT6PRMT1 | |
| SCHEMBL9379533 | 0.76 | HRH3 (0.42) | HRH3CHRM5ADRA2CTSHRCYP1A2 | |
| SCHEMBL13646385 | 0.75 | ACHE (0.56) | ACHEHRH3CHRM5ADRA2CCARM1 | |
| SCHEMBL4376306 | 0.75 | ACHE (0.56) | ACHEHRH3CHRM5ADRA2CCARM1 | |
| SCHEMBL23182993 | 0.74 | KDM4E (0.49) | ACHEHRH3KDM4ECHRM5ADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0361791-B1 | Azacyclic derivatives useful as medicaments | SMITHKLINE BEECHAM FARMA (IT) | 1995-11-08 | — | — | EP | disclosed |
| EP-0361791-A2 | Azacyclic derivatives useful as medicaments | Smithkline Beecham Farmaceutici S.p.A. (IT) | 1990-04-04 | — | — | EP | disclosed |