Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.45 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.45 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.45 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 8/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.39 |
| ▸ | HBB | P68871 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28047504 | 0.74 | LMNA (0.44) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL646139 | 0.74 | TDP1 (0.59) | TDP1LMNACRBNALDH1A1HPGD | |
| SCHEMBL400005 | 0.73 | TDP1 (1.00) | TDP1CYP1A2GRIA1GRIA2GRIA4 | |
| SCHEMBL22463402 | 0.73 | LMNA (0.41) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL11327834 | 0.73 | LMNA (0.41) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL9190653 | 0.73 | TDP1 (0.57) | TDP1CYP1A2GRIA1GRIA2GRIA4 | |
| SCHEMBL9192075 | 0.73 | TDP1 (0.57) | TDP1KDM4ECYP1A2GRIA1GRIA2 | |
| SCHEMBL4379234 | 0.73 | LMNA (0.46) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL18659115 | 0.73 | LMNA (0.41) | KDM4ECYP1A2GRIA1GRIA2GRIA3 | |
| SCHEMBL13067325 | 0.73 | LMNA (0.42) | KDM4ECYP1A2GRIA1GRIA2GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-56128769-A | — | — | None | — | — | JP | disclosed |
| CN-116457339-A | Tricyclic compounds degrading novel substrates for medical treatment | C4医药公司 | 2023-07-18 | — | — | CN | disclosed |
| WO-2017053391-A1 | MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-03-30 | — | — | WO | disclosed |
| CN-102439040-A | anti-TNF-alpha antibodies and uses thereof | FACET BIOTECH CORP | 2012-05-02 | — | — | CN | disclosed |
| EP-2280281-A1 | 5-fluoro-uracil immunoassay | Saladax Biomedical Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| EP-0425669-B1 | 1-AMINO-5-HALOGENOURACILS, PROCESS FOR THEIR PREPARATION, AND CENTRAL NERVOUS SYSTEM DEPRESSANTS CONTAINING SAME AS ACTIVE INGREDIENT | YAMASA SHOYU KK (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5334593-A | Anxiolytic drugs | YAMASA SHOYU KABUSHIKI KAISHA (JP) | 1994-08-02 | — | — | US | disclosed |
| US-5252576-A | 1-amino-5-halogenouracils, process for their preparation, and central nervous system depressants containing same as active ingredient | YAMASA SHOYU KABUSHIKI KAISHA (JP) | 1993-10-12 | — | — | US | disclosed |
| EP-0509098-A1 | ATARACTIC | Yamasa Shoyu Kabushiki Kaisha (JP) | 1992-10-21 | — | — | EP | disclosed |
| EP-0425669-A1 | 1-AMINO-5-HALOGENOURACILS, PROCESS FOR THEIR PREPARATION, AND CENTRAL NERVOUS SYSTEM DEPRESSANTS CONTAINING SAME AS ACTIVE INGREDIENT | Yamasa Shoyu Kabushiki Kaisha also trading as Yamasa Corporation (JP) | 1991-05-08 | — | — | EP | disclosed |
| JP-S56128769-A | AMINO-5-FLUOROURACIL DERIVATIVE AND ITS PREPARATION | TAIHO YAKUHIN KOGYO KK | 1981-10-08 | — | — | JP | disclosed |