SCHEMBL919279

SCHEMBL919279

CC#COc1c(C)nn(C)c(=O)c1-c1c(C)cc(Cl)cc1Cl

nearest known ligand 0.33

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 1/20 0.33
▸ KMT2A Q03164 2/20 0.32
▸ MEN1 O00255 1/20 0.32
▸ HPGD P15428 1/20 0.32
▸ SMN1; SMN2 Q16637 1/20 0.32
▸ NPSR1 Q6W5P4 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL919364 0.75 MAPT (0.38) MAPTKMT2AMEN1HPGDSMN1; SMN2
SCHEMBL1517467 0.68 HTR2A (0.34) MAPTKMT2AMEN1SMN1; SMN2
SCHEMBL3789703 0.67 MAPK8 (0.38) MAPTKMT2AMEN1HPGDSMN1; SMN2
SCHEMBL513319 0.67 NMT1 (0.36) KMT2AHPGD
SCHEMBL3805545 0.67 CA1 (0.38) MAPTKMT2AHPGDSMN1; SMN2
SCHEMBL1517574 0.65 MAPT (0.37) MAPTHPGDSMN1; SMN2
SCHEMBL1517630 0.62 NR2F2 (0.35) MAPTKMT2AMEN1
SCHEMBL919414 0.62 KMT2A (0.37) MAPTKMT2AMEN1HPGDSMN1; SMN2
SCHEMBL510389 0.60 MAPT (0.32) MAPTSMN1; SMN2
SCHEMBL18191121 0.58 KMT2A (0.32) MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20110003692-A1 HERBICIDALLY AND INSECTICIDALLY ACTIVE PHENYL-SUBSTITUTED PYRIDAZINONES BAYER CROPSCIENCE AG (DE) 2011-01-06 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110003692-A1 HERBICIDALLY AND INSECTICIDALLY ACTIVE PHENYL-SUBSTITUTED PYRIDAZINONES CYP4X1, PRDX1, PNPO MAPT 4507/4885KMT2A 1579/4885MEN1 4643/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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