Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 2/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.38 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 3/20 | 0.34 |
| ▸ | BRD2 | P25440 | 3/20 | 0.34 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.34 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL919364 | 0.92 | MAPT (0.38) | MAPK8MAPK9CDK8ACVR1MAPT | |
| SCHEMBL1517630 | 0.90 | NR2F2 (0.35) | MAPK8MAPK9CDK8ACVR1MAPT | |
| SCHEMBL469635 | 0.89 | KDM4E (0.39) | CDK8ACVR1MAPTLMNATP53 | |
| SCHEMBL510530 | 0.83 | MAPK8 (0.36) | MAPK8MAPK9CDK8ACVR1MAPT | |
| SCHEMBL919414 | 0.80 | KMT2A (0.37) | MAPK8MAPK9MAPTLMNAALDH1A1 | |
| SCHEMBL16642353 | 0.78 | CRHR1 (0.38) | CDK8ACVR1MAPTLMNATP53 | |
| SCHEMBL513374 | 0.77 | NPC1 (0.39) | MAPK8MAPK9CDK8ACVR1MAPT | |
| SCHEMBL2487475 | 0.77 | NMT1 (0.39) | MAPK8MAPK9CDK8ACVR1MAPT | |
| SCHEMBL513119 | 0.76 | KDM4E (0.33) | CDK8ACVR1LMNAHPGD | |
| SCHEMBL466412 | 0.75 | MAPT (0.36) | CDK8ACVR1MAPTLMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2204366-A1 | Herbicidal and insecticidal phenyl-substituted pyridazinones | Bayer CropScience AG (DE) | 2010-07-07 | — | — | EP | disclosed |