Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 7/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9196504 | 0.97 | NPC1 (0.39) | CYP2A6MAOAMAOBNPC1POLB | |
| SCHEMBL9201268 | 0.95 | CYP2A6 (0.38) | CYP2A6MAOAMAOBNPC1POLB | |
| SCHEMBL9225508 | 0.81 | MAPT (0.39) | CYP2A6MAOAMAOBPOLBPARP1 | |
| SCHEMBL9196127 | 0.79 | NPC1 (0.51) | NPC1POLBMEN1KMT2AHTT | |
| SCHEMBL9197570 | 0.79 | PARP1 (0.43) | NPC1POLBPARP1KMT2AHTT | |
| SCHEMBL9199522 | 0.77 | SLC6A3 (0.40) | NPC1POLBMEN1KMT2AHTT | |
| SCHEMBL9199731 | 0.76 | NPC1 (0.40) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9200340 | 0.75 | NPC1 (0.36) | NPC1POLBPARP1MEN1KMT2A | |
| SCHEMBL9205975 | 0.75 | CYP2A6 (0.38) | CYP2A6MAOAMAOBNPC1POLB | |
| SCHEMBL9280066 | 0.75 | CHRM5 (0.46) | NPC1POLBHTTSMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575425-B1 | USE OF OXAZOLO- 2,3-a]ISOINDOLE AND IMIDAZO 2,1-a]ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS, AND NEW OXAZOLO 2,3-a]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-10-11 | — | — | EP | disclosed |