Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 6/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | HTT | P42858 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9201251 | 0.87 | AKR1C3 (0.40) | POLBMEN1KMT2AHTTSMN1; SMN2 | |
| SCHEMBL9196127 | 0.77 | NPC1 (0.51) | NPC1POLBUSP2MEN1KMT2A | |
| SCHEMBL9195166 | 0.75 | CYP2A6 (0.40) | NPC1POLBHTR2AHTR2CHTR2B | |
| SCHEMBL9196504 | 0.75 | NPC1 (0.39) | NPC1POLBHTR2AHTR2CHTR2B | |
| SCHEMBL9200274 | 0.74 | POLB (0.42) | NPC1POLBUSP2PARP1MEN1 | |
| SCHEMBL9199522 | 0.73 | SLC6A3 (0.40) | NPC1POLBUSP2HTR2CMEN1 | |
| SCHEMBL9201037 | 0.73 | RXFP1 (0.42) | NPC1POLBUSP2PARP1MEN1 | |
| SCHEMBL9280066 | 0.73 | CHRM5 (0.46) | NPC1POLBHTTSMN1; SMN2MAPT | |
| SCHEMBL9201232 | 0.73 | NPC1 (0.38) | NPC1POLBUSP2PARP1MEN1 | |
| SCHEMBL9214415 | 0.73 | NPC1 (0.36) | NPC1POLBUSP2HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575425-B1 | USE OF OXAZOLO- 2,3-a]ISOINDOLE AND IMIDAZO 2,1-a]ISOINDOLE DERIVATIVES AS ANTIVIRAL DRUGS, AND NEW OXAZOLO 2,3-a]ISOINDOLE DERIVATIVES | BOEHRINGER MANNHEIM GMBH (DE) | 1995-10-11 | — | — | EP | disclosed |