Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 8/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.33 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9522462 | 0.76 | TAAR1 (0.47) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1507905 | 0.69 | TAAR1 (0.61) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL1679282 | 0.69 | TAAR1 (0.64) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL8307737 | 0.68 | TAAR1 (0.59) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL9433627 | 0.68 | TAAR1 (0.40) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL11103008 | 0.67 | TAAR1 (0.39) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL954267 | 0.67 | TAAR1 (0.53) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL8522992 | 0.67 | ADRA2A (0.55) | TAAR1HTR1AADRA2AADRA2BADRA2C | |
| SCHEMBL10724542 | 0.66 | TBXAS1 (0.46) | TAAR1HTR1A | |
| Hydrochloric Acid SCHEMBL1507828 | 0.66 | ADRA2A (0.57) | TAAR1HTR1AADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1049157-A | The preparation method of cycloalkanylpyrrole | SCHERING AG (DE) | 1991-02-13 | — | — | CN | claimed |
| EP-0411735-B1 | Cycloalkylenazoles, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicines | SCHERING AG (DE) | 1995-05-17 | — | — | EP | disclosed |
| US-5411982-A | Cycloalkylene azoles, and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-05-02 | — | — | US | disclosed |
| CN-1024345-C | Process for preparing cycloalkanylpyrrole | SCHERING AG (DE) | 1994-04-27 | — | — | CN | disclosed |
| US-5280035-A | Cycloalkylene azoles and their use as aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-01-18 | — | — | US | disclosed |
| EP-0573529-A1 | TRIHETEROARYLMETHANES, METHOD FOR PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE TO MANUFACTURE DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-12-15 | — | — | EP | disclosed |
| WO-1992015578-A1 | TRIHETEROARYLMETHANES, METHOD FOR PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE TO MANUFACTURE DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-09-17 | — | — | WO | disclosed |
| EP-0501592-A1 | Triheteroarylmethanes, process for their preparation, pharmaceutical compositions containing them and their use for the preparation of medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-09-02 | — | — | EP | disclosed |
| US-5135937-A | Aromatase inhibitors | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-08-04 | — | — | US | disclosed |
| WO-1991001975-A1 | CYCLOALKYLENAZOLES, PROCESS FOR PREPARING THEM, PHARMACEUTICAL PREPARATIONS CONTAINING THEM AND THEIR USE TO MANUFACTURE DRUGS | SCHERING AKTIENGESELLSCHAFT BERLIN UND BERGKAMEN (DE) | 1991-02-21 | — | — | WO | disclosed |
| CN-1049157-A | The preparation method of cycloalkanylpyrrole | SCHERING AG (DE) | 1991-02-13 | — | — | CN | disclosed |
| EP-0411735-A1 | Cycloalkylenazoles, process for their preparation, pharmaceutical preparations containing them and their use for the preparation of medicines | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-02-06 | — | — | EP | disclosed |