Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.39 |
| ▸ | TOP1 | P11387 | 2/20 | 0.36 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.34 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.34 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.34 |
| ▸ | GCGR | P47871 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | STAT1 | P42224 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | FABP2 | P12104 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514015 | 0.94 | HMGCR (0.42) | HMGCRPTGS2GCGRPTGS1 | |
| SCHEMBL9514348 | 0.82 | CA1 (0.47) | HMGCRPTGS2MEN1FABP2TSHR | |
| SCHEMBL24268972 | 0.80 | CA1 (0.43) | PTGS2 | |
| SCHEMBL9515012 | 0.80 | HMGCR (0.44) | HMGCRPTGS2GCGRPTGS1 | |
| SCHEMBL9857638 | 0.79 | HMGCR (0.42) | HMGCRGCGR | |
| SCHEMBL9520263 | 0.78 | HMGCR (0.39) | HMGCRUSP1WDR48PTGS2HPRT1 | |
| SCHEMBL9857543 | 0.78 | HMGCR (0.44) | HMGCRPTGS2MEN1FABP2TSHR | |
| SCHEMBL9512239 | 0.74 | CA1 (0.53) | HMGCRGCGRTSHRPTGS1HTR2C | |
| SCHEMBL9512819 | 0.74 | HMGCR (0.51) | HMGCRKMT2A | |
| SCHEMBL28968808 | 0.72 | HMGCR (0.40) | HMGCRPTGS2GCGRPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418648-B1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AG (DE) | 1995-01-11 | — | — | EP | disclosed |
| US-5294724-A | Anticholesterol agents | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-03-15 | — | — | US | disclosed |
| EP-0418648-A1 | 4-Hydroxytetrahydropyran-2-ones as well as the corresponding dehydroxy carbon acid derivatives, salts and esters, process for their preparation, pharmaceutical preparations as well as precursors | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-27 | — | — | EP | disclosed |