Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
| ▸ | CA9 | Q16790 | 1/20 | 0.35 |
| ▸ | USP1 | O94782 | 1/20 | 0.35 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | HPRT1 | P00492 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9857896 | 0.84 | PTGS2 (0.39) | MEN1RAB9AKMT2APTGS2USP1 | |
| SCHEMBL9857094 | 0.81 | PTGS2 (0.41) | HMGCRMEN1RAB9AKMT2APTGS2 | |
| SCHEMBL9196802 | 0.78 | HMGCR (0.39) | HMGCRMEN1KMT2APTGS2USP1 | |
| SCHEMBL9514348 | 0.78 | CA1 (0.47) | HMGCRMEN1KMT2APTGS2CA1 | |
| SCHEMBL9042683 | 0.78 | CA12 (0.43) | PTGS2CA12CA1CA2CA9 | |
| SCHEMBL9857627 | 0.78 | AKR1C3 (0.36) | — | |
| SCHEMBL9857543 | 0.78 | HMGCR (0.44) | HMGCRMEN1RAB9AKMT2APTGS2 | |
| SCHEMBL9857638 | 0.76 | HMGCR (0.42) | HMGCR | |
| SCHEMBL8878341 | 0.76 | HMGCR (0.57) | HMGCR | |
| SCHEMBL8876648 | 0.75 | HMGCR (0.59) | HMGCRMEN1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0302253-B1 | 3-DEMETHYL-4-FLUORO-MEVALONIC-ACID DERIVATIVES, PROCESS FOR THEIR PREPARATION, PHARMACEUTICAL PREPARATIONS BASED ON THOSE COMPOUNDS, THEIR USE AND INTERMEDIATES | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-04-07 | — | — | EP | disclosed |
| US-4898868-A | ANTICHOLESTEROL AGENTS; LACTONE OR FREE ACID FORM | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| EP-0302253-A1 | 3-Demethyl-4-fluoro-mevalonic-acid derivatives, process for their preparation, pharmaceutical preparations based on those compounds, their use and intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-02-08 | — | — | EP | disclosed |