Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.53 |
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | HMGCR | P04035 | 2/20 | 0.44 |
| ▸ | GCGR | P47871 | 2/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.37 |
| ▸ | GABRB1 | P18505 | 4/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.35 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9514348 | 0.94 | CA1 (0.47) | CA1CA2HMGCRGABRA1GABRB1 | |
| SCHEMBL10026552 | 0.89 | CA1 (0.68) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL8780176 | 0.85 | GABRA1 (0.50) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL22888675 | 0.84 | CA1 (0.55) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL9199239 | 0.83 | CA1 (0.41) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL31603747 | 0.82 | CA1 (0.57) | CA1CA2GABRA1GABRB1GABRB2 | |
| SCHEMBL9516053 | 0.81 | CA1 (0.39) | CA1CA2 | |
| SCHEMBL9197287 | 0.80 | HMGCR (0.38) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL8780227 | 0.80 | HMGCR (0.50) | CA1CA2HMGCRGCGRRPS6KA3 | |
| SCHEMBL9514015 | 0.79 | HMGCR (0.42) | CA1CA2HMGCRGCGRIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0341681-B1 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5166171-A | Compounds for treatment of artheriosclerosis and hypercholesterolemia | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-24 | — | — | US | disclosed |
| EP-0341681-A2 | 6-Phenoxymethyl-4-hydroxytetrahydropyran-2-ones and 6-thiophenoxymethyl-4-hydroxytetrahydropyran-2-ones, the corresponding dihydrocarboxylic-acid derivatives, salts and esters, process for preparing these compounds, their use as medicines, pharmaceutical compositions and phenols and thiophenols | HOECHST AKTIENGESELLSCHAFT (DE) | 1989-11-15 | — | — | EP | disclosed |