Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8939990 | 0.89 | MEN1 (0.43) | HTR4 | |
| SCHEMBL8940096 | 0.78 | MEN1 (0.46) | HTR4 | |
| Zatosetron SCHEMBL466401 | 0.77 | HTR3A (0.51) | HTR4 | |
| SCHEMBL8939935 | 0.77 | HTR3A (0.46) | HTR4 | |
| Zatosetron SCHEMBL466399 | 0.77 | HTR3A (0.51) | HTR4 | |
| SCHEMBL8939946 | 0.77 | HTR4 (0.42) | HTR4 | |
| Zatosetron SCHEMBL466400 | 0.77 | HTR3A (0.51) | HTR4 | |
| SCHEMBL8939947 | 0.77 | L3MBTL1 (0.55) | — | |
| SCHEMBL8940050 | 0.76 | HTR4 (0.43) | HTR4 | |
| SCHEMBL8940123 | 0.76 | HTR4 (0.48) | HTR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307172-B1 | Improvements in or relating to specific 5-HT3 antagonists | LILLY CO ELI (US) | 1995-10-11 | — | — | EP | disclosed |
| EP-0307172-A2 | Improvements in or relating to specific 5-HT3 antagonists | ELI LILLY AND COMPANY (US) | 1989-03-15 | — | — | EP | disclosed |