Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9193569 | 0.82 | KCNH2 (0.48) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL1334676 | 0.82 | KCNH2 (0.48) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL402734 | 0.74 | LTA4H (0.52) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30957038 | 0.74 | KCNH2 (0.42) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL29240323 | 0.74 | KCNH2 (0.42) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9292674 | 0.73 | ALDH1A1 (0.43) | RAB9ASMN1; SMN2TDP1NPC1ALDH1A1 | |
| SCHEMBL4338418 | 0.71 | KCNH2 (0.58) | KCNH2KDM4EMAPTTDP1ALDH1A1 | |
| SCHEMBL1590727 | 0.71 | KCNH2 (0.50) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL3143466 | 0.70 | DPP4 (0.47) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 | |
| SCHEMBL9456798 | 0.70 | ERN1 (0.47) | KCNH2KDM4EMAPTRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656900-A4 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS. | MERCK & CO INC (US) | 1995-09-06 | — | — | EP | disclosed |
| EP-0656900-A1 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS | MERCK & CO. INC. (US) | 1995-06-14 | — | — | EP | disclosed |
| US-5342933-A | Cationic-2-heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1994-08-30 | — | — | US | disclosed |
| WO-1994005669-A1 | CATIONIC-2-HETEROARYLPHENYL-CARBAPENEM ANTIBACTERIAL AGENTS | MERCK & CO., INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| US-5292879-A | Intermediates for preparing cationic-2-heteroaryl-phenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1994-03-08 | — | — | US | disclosed |
| US-5220011-A | Antibiotics effective against resistant grampositive bacteria | MERCK & CO., INC. (US) | 1993-06-15 | — | — | US | disclosed |
| EP-0520553-A1 | 2-Heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO. INC. (US) | 1992-12-30 | — | — | EP | disclosed |
| US-5143914-A | 2-heteroarylphenyl-carbapenem antibacterial agents | MERCK & CO., INC. (US) | 1992-09-01 | — | — | US | disclosed |