Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 10/20 | 0.53 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.53 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.51 |
| ▸ | PARP11 | Q9NR21 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9447546 | 1.00 | PARP1 (0.53) | PARP1TRPM2PARP10PARP11ALDH1A1 | |
| SCHEMBL9447511 | 1.00 | PARP1 (0.53) | PARP1TRPM2PARP10PARP11ALDH1A1 | |
| SCHEMBL8057578 | 0.94 | PARP1 (0.49) | PARP1TRPM2PARP10PARP11ALDH1A1 | |
| SCHEMBL9537613 | 0.81 | ALDH1A1 (0.50) | PARP1ALDH1A1GLAMRGPRX4TP53 | |
| SCHEMBL8051434 | 0.80 | MRGPRX4 (0.52) | PARP1TRPM2ALDH1A1GLAMRGPRX4 | |
| SCHEMBL9128670 | 0.80 | MRGPRX4 (0.52) | PARP1TRPM2ALDH1A1GLAMRGPRX4 | |
| SCHEMBL7581574 | 0.79 | PARP1 (0.58) | PARP1TRPM2PARP10PARP11HDAC1 | |
| SCHEMBL4717294 | 0.78 | PARP1 (0.65) | PARP1TRPM2PARP10PARP11HDAC1 | |
| SCHEMBL11805028 | 0.78 | ALDH1A1 (0.48) | PARP1ALDH1A1GLAMRGPRX4TP53 | |
| SCHEMBL9196870 | 0.77 | PARP1 (0.66) | PARP1TRPM2PARP10PARP11HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0355750-B1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER LAMBERT CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5177075-A | Antitumor agents | WARNER-LAMBERT COMPANY (US) | 1993-01-05 | — | — | US | disclosed |
| EP-0355750-A1 | Substituted dihydroisoquinolinones and related compounds as potentiators of the lethal effects of radiation and certain chemotherapeutic agents; selected compounds, analogs and process | WARNER-LAMBERT COMPANY (US) | 1990-02-28 | — | — | EP | disclosed |