Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | GLA | P06280 | 1/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | BRD4 | O60885 | 2/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8051434 | 0.93 | MRGPRX4 (0.52) | ALDH1A1GLAABCB1TSHRTP53 | |
| SCHEMBL9128670 | 0.93 | MRGPRX4 (0.52) | ALDH1A1GLAABCB1TSHRTP53 | |
| SCHEMBL11805028 | 0.92 | ALDH1A1 (0.48) | ALDH1A1GLAABCB1TSHRTP53 | |
| SCHEMBL11634077 | 0.82 | HTR2A (0.60) | ABCB1CYP3A4MRGPRX4SLC6A4ADRB2 | |
| SCHEMBL4814894 | 0.81 | PKM (0.61) | ALDH1A1ABCB1MRGPRX4LMNAPKM | |
| SCHEMBL9197129 | 0.81 | PARP1 (0.53) | ALDH1A1GLATSHRTP53CYP3A4 | |
| SCHEMBL9447546 | 0.81 | PARP1 (0.53) | ALDH1A1GLATSHRTP53CYP3A4 | |
| SCHEMBL9447511 | 0.81 | PARP1 (0.53) | ALDH1A1GLATSHRTP53CYP3A4 | |
| SCHEMBL8057578 | 0.80 | PARP1 (0.49) | ALDH1A1GLATSHRTP53CYP3A4 | |
| SCHEMBL9311184 | 0.78 | ALDH1A1 (0.56) | ALDH1A1GLATSHRTP53CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5254595-A | Aryloxypropanolaminotetralins, a process for their preparation and pharmaceutical compositions containing them | ELF SANOFI (FR) | 1993-10-19 | — | — | US | disclosed |
| EP-0375560-B1 | ARYLOXYPROPANOLAMINOTETRALINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | ELF SANOFI (FR) | 1993-05-12 | — | — | EP | disclosed |
| EP-0375560-A1 | Aryloxypropanolaminotetralines, process for their preparation and pharmaceutical compositions containing same | ELF SANOFI (FR) | 1990-06-27 | — | — | EP | disclosed |
| EP-0043971-B1 | INDANONEOXYALKYLPIPERAZINE DERIVATIVES, THE PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | BASF Aktiengesellschaft (DE) | 1984-12-19 | — | — | EP | disclosed |
| US-4435397-A | ADRENERGIC BLOCKING AGENTS, 4-(3-ARYLOXY-2-HYDROXYPROPYL) SUBSTITUTED | NIPPON SHINYAKU CO., LTD. (JP) | 1984-03-06 | — | — | US | disclosed |
| EP-0043971-A1 | Indanoneoxyalkylpiperazine derivatives, the preparation thereof and pharmaceutical compositions containing the same | BASF Aktiengesellschaft (DE) | 1982-01-20 | — | — | EP | disclosed |
| US-4109088-A | ANTIDEPRESSANTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1978-08-22 | — | — | US | disclosed |