Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 5/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 5/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 5/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.38 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9191384 | 0.81 | SLC6A2 (0.42) | SLC6A2HTTCDK1 | |
| SCHEMBL9193439 | 0.79 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL9194252 | 0.74 | PDE4A (0.64) | HTT | |
| SCHEMBL31061395 | 0.73 | EGFR (0.59) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL9191914 | 0.71 | PI4KA (0.47) | PI4KAPI4K2BPI4K2API4KBEGFR | |
| SCHEMBL9193101 | 0.70 | LMNA (0.66) | TSHRCYP2C19HTT | |
| SCHEMBL9197538 | 0.69 | CDK1 (0.34) | SLC6A2HTTCDK1 | |
| SCHEMBL9848536 | 0.68 | SLC6A2 (0.46) | SLC6A2HTT | |
| SCHEMBL9194028 | 0.68 | SLC6A2 (0.46) | EGFRSLC6A2HTT | |
| SCHEMBL9150129 | 0.67 | PI4KA (0.66) | PI4KAPI4K2BPI4K2API4KBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1029968-C | Process for preparation of N-heteroaryl-purin-6-amines and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-10-11 | — | — | CN | disclosed |
| EP-0402752-B1 | N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-09-13 | — | — | EP | disclosed |
| US-5155098-A | Analgesics, anticonvulsants | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5017578-A | N-heteroaryl-purin-6-amines useful as analgesic and anticonvulsant agents | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-05-21 | — | — | US | disclosed |
| EP-0402752-A1 | N-heteroaryl-purin-6-amines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1990-12-19 | — | — | EP | disclosed |
| CN-1047866-A | The preparation method of N-heteroaryl-purine-6-amine and medicinal | HOECHST ROUSSEL PHARMA (US) | 1990-12-19 | — | — | CN | disclosed |