Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | HTT | P42858 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GALR3 | O60755 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543535 | 0.72 | KDM4C (0.42) | MAPTHTTKDM4ERAB9ALMNA | |
| SCHEMBL9194028 | 0.72 | SLC6A2 (0.46) | SLC6A2MAPTHTTRAB9ALMNA | |
| SCHEMBL9445587 | 0.71 | SLC6A2 (0.48) | SLC6A2KMT2AMEN1NPC1CDK2 | |
| SCHEMBL9191384 | 0.69 | SLC6A2 (0.42) | SLC6A2HTTRAB9ASMN1; SMN2NPC1 | |
| SCHEMBL9197685 | 0.68 | PI4KA (0.49) | SLC6A2HTT | |
| SCHEMBL9445604 | 0.68 | SLC6A2 (0.47) | SLC6A2HTTRAB9AKMT2AMEN1 | |
| SCHEMBL1898192 | 0.66 | EGFR (0.53) | MAPTHTTKDM4ERAB9ALMNA | |
| SCHEMBL8571941 | 0.66 | SLC6A2 (0.51) | SLC6A2MAPTKDM4ELMNAKMT2A | |
| SCHEMBL3263590 | 0.65 | SLC6A2 (0.58) | SLC6A2HTTKDM4ERAB9ALMNA | |
| SCHEMBL9445623 | 0.65 | SLC6A2 (0.62) | SLC6A2MAPTCDC7CDK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0417584-A2 | N-substituted-4-pyrimidinamines and -pyrimidindiamines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1991-03-20 | — | — | EP | disclosed |