Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 3/20 | 0.53 |
| ▸ | DRD3 | P35462 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198134 | 1.00 | HTR1A (0.59) | HTR1ADRD2DRD3SIGMAR1LMNA | |
| SCHEMBL9197517 | 1.00 | HTR1A (0.59) | HTR1ADRD2DRD3SIGMAR1LMNA | |
| SCHEMBL9195870 | 0.89 | DRD2 (0.59) | HTR1ADRD2DRD3POLB | |
| SCHEMBL9200413 | 0.87 | DRD2 (0.55) | HTR1ADRD2DRD3SIGMAR1LMNA | |
| SCHEMBL9202549 | 0.83 | DRD2 (0.55) | HTR1ADRD2DRD3 | |
| SCHEMBL9202889 | 0.83 | HTR1A (0.57) | HTR1ALMNAALDH1A1KMT2AHPGD | |
| SCHEMBL9196526 | 0.82 | DRD2 (0.59) | HTR1ADRD2DRD3SIGMAR1 | |
| SCHEMBL9196967 | 0.81 | DRD2 (0.53) | HTR1ADRD2DRD3SIGMAR1 | |
| SCHEMBL9197205 | 0.78 | DRD2 (0.62) | HTR1ADRD2DRD3SIGMAR1 | |
| SCHEMBL9197201 | 0.78 | DRD2 (0.62) | HTR1ADRD2DRD3SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431580-B1 | Substituted cyclohexanols as central nervous system agents | WARNER LAMBERT CO (US) | 1995-03-08 | — | — | EP | claimed |
| EP-0431580-A2 | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| EP-0431580-B1 | Substituted cyclohexanols as central nervous system agents | WARNER LAMBERT CO (US) | 1995-03-08 | — | — | EP | disclosed |
| US-5047406-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0431580-A2 | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4957921-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1990-09-18 | — | — | US | disclosed |