Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.55 |
| ▸ | DRD3 | P35462 | 10/20 | 0.55 |
| ▸ | HTR1A | P08908 | 6/20 | 0.55 |
| ▸ | HTR2A | P28223 | 6/20 | 0.55 |
| ▸ | HTR7 | P34969 | 6/20 | 0.55 |
| ▸ | DRD4 | P21917 | 6/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.55 |
| ▸ | HTR2C | P28335 | 2/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
| ▸ | DRD5 | P21918 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9195870 | 0.91 | DRD2 (0.59) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL9197517 | 0.87 | HTR1A (0.59) | DRD2DRD3HTR1ASIGMAR1LMNA | |
| SCHEMBL9198136 | 0.87 | HTR1A (0.59) | DRD2DRD3HTR1ASIGMAR1LMNA | |
| SCHEMBL9198134 | 0.87 | HTR1A (0.59) | DRD2DRD3HTR1ASIGMAR1LMNA | |
| SCHEMBL9202549 | 0.85 | DRD2 (0.55) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL9196526 | 0.85 | DRD2 (0.59) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL9196967 | 0.84 | DRD2 (0.53) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL29974343 | 0.81 | GRIN2B (0.66) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL22626906 | 0.81 | GRIN2B (0.66) | DRD2DRD3HTR1AHTR2AHTR7 | |
| SCHEMBL9197205 | 0.80 | DRD2 (0.62) | DRD2DRD3HTR1AHTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431580-B1 | Substituted cyclohexanols as central nervous system agents | WARNER LAMBERT CO (US) | 1995-03-08 | — | — | EP | claimed |
| EP-0431580-A2 | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | claimed |
| EP-0431580-B1 | Substituted cyclohexanols as central nervous system agents | WARNER LAMBERT CO (US) | 1995-03-08 | — | — | EP | disclosed |
| US-5047406-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0431580-A2 | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| EP-0431579-A2 | Substituted cyclohexenes as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4975445-A | Antidepressants | WARNER-LAMBERT COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| US-4957921-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1990-09-18 | — | — | US | disclosed |