Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTPRC | P08575 | 2/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199038 | 0.90 | NFKB1 (0.35) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9200820 | 0.87 | CYP2A6 (0.40) | MAPTALDH1A1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL9545532 | 0.84 | MAPT (0.35) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9194471 | 0.84 | GSK3B (0.47) | MAPTPDK2ALDH1A1PTPRCCTSL | |
| SCHEMBL9195303 | 0.80 | CYP2A6 (0.36) | GAAPDK2PTPRCCTSLCTSS | |
| SCHEMBL9198100 | 0.79 | NFKB1 (0.46) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9198107 | 0.79 | NFKB1 (0.46) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9545130 | 0.72 | CYP19A1 (0.37) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9545138 | 0.72 | CYP19A1 (0.37) | NFKB1NFKB2RELAGAAMAPT | |
| SCHEMBL9275393 | 0.71 | PDK2 (0.33) | GAAPDK2ALDH1A1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636132-A1 | SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021185-A1 | SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |