Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | TDP2 | O95551 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | PLCG1 | P19174 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198802 | 0.90 | NFKB1 (0.45) | NFKB1NFKB2RELAMAPTKMT2A | |
| SCHEMBL9200820 | 0.86 | CYP2A6 (0.40) | MAPTRAB9ASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL9198144 | 0.86 | LIG1 (0.36) | NFKB1NFKB2RELATP53GAA | |
| SCHEMBL9545532 | 0.82 | MAPT (0.35) | NFKB1NFKB2RELAMAPTKMT2A | |
| SCHEMBL9275393 | 0.82 | PDK2 (0.33) | KMT2AGAADDB1CRBNPDK2 | |
| SCHEMBL9194471 | 0.79 | GSK3B (0.47) | NPC1MAPTRAB9ASMN1; SMN2KMT2A | |
| SCHEMBL9195303 | 0.79 | CYP2A6 (0.36) | KMT2AGAATDP2NSD2ABL1 | |
| SCHEMBL9198107 | 0.70 | NFKB1 (0.46) | NFKB1NFKB2RELACYP19A1MAPT | |
| SCHEMBL9198100 | 0.70 | NFKB1 (0.46) | NFKB1NFKB2RELACYP19A1MAPT | |
| SCHEMBL9545138 | 0.68 | CYP19A1 (0.37) | NFKB1NFKB2RELACYP19A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636132-A1 | SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-02-01 | — | — | EP | disclosed |
| WO-1993021185-A1 | SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |