Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | APP | P05067 | 3/20 | 0.35 |
| ▸ | SNCA | P37840 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198802 | 0.84 | NFKB1 (0.45) | MAPTALDH1A1GAANFKB1NFKB2 | |
| SCHEMBL9199038 | 0.82 | NFKB1 (0.35) | MAPTGAANFKB1NFKB2RELA | |
| SCHEMBL9200820 | 0.77 | CYP2A6 (0.40) | MAPTALDH1A1MAPK1KMT2AMEN1 | |
| SCHEMBL9194471 | 0.74 | GSK3B (0.47) | MAPTALDH1A1KMT2ACYP1A2CYP2C19 | |
| SCHEMBL9195303 | 0.71 | CYP2A6 (0.36) | GAAKMT2AMEN1CYP1A2CYP2C19 | |
| SCHEMBL21048499 | 0.66 | MAPT (0.42) | MAPTAPPSNCAALDH1A1MAPK1 | |
| SCHEMBL9275393 | 0.65 | PDK2 (0.33) | ALDH1A1GAAKMT2ACYP11B2CYP1A2 | |
| SCHEMBL9198100 | 0.65 | NFKB1 (0.46) | MAPTALDH1A1GAANFKB1NFKB2 | |
| SCHEMBL9198107 | 0.65 | NFKB1 (0.46) | MAPTALDH1A1GAANFKB1NFKB2 | |
| SCHEMBL11235932 | 0.62 | ALDH1A1 (0.38) | MAPTAPPSNCAALDH1A1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993021185-A1 | SUBSTITUTED NITROGEN CONTAINING SPIRO COMPOUNDS FOR USE IN TREATING COGNITIVE DEFICITS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-10-28 | — | — | WO | disclosed |