Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.57 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.44 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | FLI1 | Q01543 | 1/20 | 0.39 |
| ▸ | EWSR1 | Q01844 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10660683 | 0.84 | HAO1 (0.58) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL4842868 | 0.79 | HAO1 (0.67) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL4707187 | 0.79 | HAO1 (0.62) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL4032443 | 0.77 | PLOD2 (0.64) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL7470538 | 0.77 | HAO1 (0.55) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL17295068 | 0.76 | HAO1 (0.58) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL5768900 | 0.76 | HAO1 (0.58) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL275400 | 0.75 | HAO1 (0.56) | HAO1PLK1TAS1R3TAS1R1MMP2 | |
| SCHEMBL522779 | 0.75 | KMT2A (0.67) | HAO1MEN1KMT2ARAB9ANPC1 | |
| SCHEMBL6302968 | 0.75 | HAO1 (0.56) | HAO1PLK1TAS1R3TAS1R1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |