Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLOD2 | O00469 | 3/20 | 0.64 |
| ▸ | PLOD3 | O60568 | 2/20 | 0.57 |
| ▸ | PLOD1 | Q02809 | 2/20 | 0.57 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.55 |
| ▸ | PLK1 | P53350 | 1/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP9 | P14780 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.39 |
| ▸ | RAB9A | P51151 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312596 | 0.85 | HAO1 (0.46) | PLOD2PLOD3PLOD1HAO1PLK1 | |
| SCHEMBL1593867 | 0.80 | PLOD2 (0.70) | PLOD2PLOD3PLOD1PTPN1SMN1; SMN2 | |
| SCHEMBL22804475 | 0.80 | PLOD2 (0.60) | PLOD2PLOD3PLOD1HAO1PTPN1 | |
| SCHEMBL7202272 | 0.79 | HAO1 (0.50) | PLOD2HAO1PLK1EPHX2NR1H4 | |
| SCHEMBL10613378 | 0.79 | PLOD2 (0.68) | PLOD2PLOD3PLOD1PTPN1SMN1; SMN2 | |
| SCHEMBL711849 | 0.78 | PLOD2 (1.00) | PLOD2PLOD3PLOD1PTPN1SMN1; SMN2 | |
| SCHEMBL4842868 | 0.78 | HAO1 (0.67) | HAO1PLK1EPHX2NR1H4TAS1R3 | |
| SCHEMBL4707187 | 0.78 | HAO1 (0.62) | HAO1PLK1EPHX2NR1H4TAS1R3 | |
| SCHEMBL1095373 | 0.78 | PLOD2 (0.72) | PLOD2PLOD3PLOD1PTPN1NPC1 | |
| SCHEMBL9199040 | 0.77 | HAO1 (0.57) | HAO1PLK1EPHX2NR1H4TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 51 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025002289-A1 | PYRAZOLOHETEROARYL COMPOUND, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 湖南九典制药股份有限公司 | 2025-01-02 | — | — | WO | disclosed |
| CN-111344362-B | Ink composition and printed matter | 大日本印刷株式会社 | 2022-07-05 | — | — | CN | disclosed |
| CN-111344361-A | Ink composition, printed matter, and method for determining authenticity | 大日本印刷株式会社 | 2020-06-26 | — | — | CN | disclosed |
| CN-111344362-A | Ink composition and printed matter | 大日本印刷株式会社 | 2020-06-26 | — | — | CN | disclosed |
| EP-1492773-B1 | 4-(HETEROCYCLYL)-BENZENESULFOXIMINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | CADILA HEALTHCARE LTD (IN) | 2009-02-04 | — | — | EP | disclosed |
| EP-1493735-B1 | PYRIMIDINE DERIVATIVES USEFUL AS SELECTIVE COX-2 INHIBITORS | GLAXO GROUP LTD (GB) | 2008-10-29 | — | — | EP | disclosed |
| US-7348342-B2 | Heterocyclic compounds process for their preparation and pharmaceutical compositions containing them and their use in medicine | CADILA HEALTHCARE LIMITED (IN) | 2008-03-25 | — | — | US | disclosed |
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | GLAXO GROUP LIMITED (GB) | 2007-11-22 | — | — | US | disclosed |
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | US | disclosed |
| US-20060194824-A1 | Compositions containing pyrimidine derivatives as inhibitors of cox-2 | GLAXO GROUP LIMITED (GB) | 2006-08-31 | — | — | US | disclosed |
| WO-2001038311-A2 | PYRIMIDINE DERIVATIVES AS SELECTIVE INHIBITORS OF COX-2 | GLAXO GROUP LIMITED (GB) | 2001-05-31 | — | — | WO | disclosed |
| EP-1017678-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-07-12 | — | — | EP | disclosed |
| WO-2000018741-A2 | PYRAZOLE COMPOUNDS AS COX-2 INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-06 | — | — | WO | disclosed |
| WO-1999015505-A1 | 1,5-DIPHENYLPYRAZOLE DERIVATIVES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1999-04-01 | — | — | WO | disclosed |
| US-5670533-A | ANTIINFLAMMATORY AGENTS, ANALGESICS OR ANTIRHEUMATIC DISEASES | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1997-09-23 | — | — | US | disclosed |
| US-5550147-A | ANTIINFLAMMATORY AGENTS, ANALGESICS, ANTITHROMBOTIC AGENTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-08-27 | — | — | US | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| EP-0554829-A2 | Pyrazole derivatives with antiinflammatory, analgesic and antithrombolic activity | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1993-08-11 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070270428-A1 | Use of Cyclooxygenase-2 Inhibitors for the Treatment of Depressive Disorders | TPH2, PTGS2, PTGES2 | PLOD2 639/4885PLOD3 3110/4885PLOD1 1321/4885 |
| US-20060194824-A1 | Compositions containing pyrimidine derivatives as inhibitors of cox-2 | DPYD, PTGS2, TYMP | PLOD2 1761/4885PLOD3 4082/4885PLOD1 3098/4885 |
| US-20070142411-A1 | Use of cyclooxygenase-2 selective inhibitors for the treatment of schizophrenic disorders | PTGES2, PTGER2, PTGDR2 | PLOD2 2058/4885PLOD3 4553/4885PLOD1 2943/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.