Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 7/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | ATM | Q13315 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8201118 | 0.82 | CHRNB2 (0.39) | ALDH1A1MAPTTDP1MEN1KMT2A | |
| SCHEMBL1018016 | 0.76 | NAMPT (0.50) | NAMPTALDH1A1SMN1; SMN2MAPTCYP1A2 | |
| SCHEMBL9198607 | 0.75 | MAPT (0.36) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL11002701 | 0.69 | ALDH1A1 (0.55) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL9509362 | 0.68 | MAPT (0.50) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL2103568 | 0.67 | MAPK1 (0.55) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL1532324 | 0.67 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL1706262 | 0.67 | MAPT (0.53) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 | |
| SCHEMBL3630547 | 0.67 | FASN (0.52) | NAMPTALDH1A1SMN1; SMN2MAPK1TDP1 | |
| SCHEMBL15659596 | 0.66 | TSHR (0.53) | ALDH1A1SMN1; SMN2MAPTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484223-B1 | 3-Cycloalkylpropanamides, their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-03-08 | — | — | EP | disclosed |
| US-5384423-A | Intermediates for antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1995-01-24 | — | — | US | disclosed |
| US-5240960-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0484223-A2 | 3-Cycloalkylpropanamides, their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |