Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.35 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.35 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9204753 | 0.86 | CHRNB2 (0.44) | CHRNB2CHRNB4CHRNA3CHRNA4PDK2 | |
| SCHEMBL9199227 | 0.82 | NAMPT (0.40) | MEN1MAPTKMT2AALDH1A1TDP1 | |
| SCHEMBL9819113 | 0.79 | ALDH1A1 (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4MAPT | |
| SCHEMBL9198607 | 0.79 | MAPT (0.36) | CHRNB2CHRNB4CHRNA3CHRNA4MEN1 | |
| SCHEMBL9205909 | 0.76 | PGR (0.35) | PDK2GPBAR1 | |
| SCHEMBL9638607 | 0.74 | ALDH1A1 (0.31) | MAPTALDH1A1 | |
| SCHEMBL3916812 | 0.73 | PDK2 (0.59) | CHRNB2CHRNB4CHRNA3CHRNA4PDK2 | |
| SCHEMBL9818892 | 0.71 | CYP11B1 (0.43) | GPBAR1LIPEALDH1A1POLBTDP1 | |
| SCHEMBL9818860 | 0.71 | CYP11B1 (0.43) | GPBAR1LIPEALDH1A1POLBTDP1 | |
| SCHEMBL24339824 | 0.69 | MLYCD (0.56) | CHRNB2CHRNB4CHRNA3CHRNA4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787491-B1 | PREVENTIVE AND REMEDY FOR TYPE I ALLERGIC DISEASES | AVENTIS PHARMA LTD (JP) | 2000-07-26 | — | — | EP | claimed |
| US-5814649-A | ALLERGIC DISEASES AND TREATMENT WITH AROMATIC AMIDES WITH IMMUNOGLOBULIN INHIBITORS | HOECHST PHARMACEUTICALS & CHEMICALS K.K. (JP) | 1998-09-29 | — | — | US | claimed |
| EP-0787491-A1 | PREVENTIVE AND REMEDY FOR TYPE I ALLERGIC DISEASES | HOECHST JAPAN LIMITED (JP) | 1997-08-06 | — | — | EP | claimed |
| EP-0787491-B1 | PREVENTIVE AND REMEDY FOR TYPE I ALLERGIC DISEASES | AVENTIS PHARMA LTD (JP) | 2000-07-26 | — | — | EP | disclosed |
| US-5814649-A | ALLERGIC DISEASES AND TREATMENT WITH AROMATIC AMIDES WITH IMMUNOGLOBULIN INHIBITORS | HOECHST PHARMACEUTICALS & CHEMICALS K.K. (JP) | 1998-09-29 | — | — | US | disclosed |
| EP-0787491-A1 | PREVENTIVE AND REMEDY FOR TYPE I ALLERGIC DISEASES | HOECHST JAPAN LIMITED (JP) | 1997-08-06 | — | — | EP | disclosed |
| EP-0484223-B1 | 3-Cycloalkylpropanamides, their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL UCLAF (FR) | 1995-03-08 | — | — | EP | disclosed |
| US-5384423-A | Intermediates for antiinflammatory agents | ROUSSEL-UCLAF (FR) | 1995-01-24 | — | — | US | disclosed |
| US-5240960-A | Antiinflammatory agents | ROUSSEL UCLAF (FR) | 1993-08-31 | — | — | US | disclosed |
| EP-0484223-A2 | 3-Cycloalkylpropanamides, their tautomers and salts, process for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1992-05-06 | — | — | EP | disclosed |