Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 7/20 | 0.79 |
| ▸ | AGTR2 | P50052 | 7/20 | 0.79 |
| ▸ | TBXA2R | P21731 | 5/20 | 0.56 |
| ▸ | DRD2 | P14416 | 2/20 | 0.56 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.54 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198766 | 0.92 | AGTR1 (0.79) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9197947 | 0.89 | AGTR1 (1.00) | AGTR1AGTR2TBXA2R | |
| SCHEMBL9196115 | 0.87 | AGTR1 (0.61) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9198925 | 0.85 | AGTR1 (0.78) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9275378 | 0.85 | AGTR1 (0.78) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9198105 | 0.81 | AGTR1 (0.78) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL7673045 | 0.81 | AGTR1 (0.60) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9200654 | 0.80 | AGTR1 (1.00) | AGTR1AGTR2 | |
| SCHEMBL7987035 | 0.79 | PPARG (0.70) | AGTR1AGTR2TBXA2RDRD2TLR7 | |
| SCHEMBL9201172 | 0.78 | DRD2 (0.78) | AGTR1AGTR2TBXA2RDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0399732-B1 | Benzimidazole derivatives | ZENECA LTD (GB) | 1995-07-26 | — | — | EP | disclosed |
| US-5171748-A | For hypertension, cardiovascular disorders | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-12-15 | — | — | US | disclosed |
| EP-0399732-A1 | Benzimidazole derivatives | ZENECA LIMITED (GB) | 1990-11-28 | — | — | EP | disclosed |