Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 4/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.32 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.32 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5284629 | 0.76 | ALDH1A1 (0.39) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL2331142 | 0.74 | ALDH1A1 (0.41) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL28499236 | 0.72 | TSHR (0.35) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL5289688 | 0.71 | ALDH1A1 (0.36) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL907611 | 0.65 | ALDH1A1 (0.57) | ALDH1A1KMT2ATSHRSMN1; SMN2 | |
| SCHEMBL8882203 | 0.64 | KMT2A (0.41) | ALDH1A1MEN1KMT2ATSHRSLC1A3 | |
| SCHEMBL8614585 | 0.64 | ALDH1A1 (0.34) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL7132195 | 0.63 | ALDH1A1 (0.38) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL23536852 | 0.63 | ALDH1A1 (0.37) | ALDH1A1CYP3A4MEN1KMT2AMAPT | |
| SCHEMBL8545819 | 0.63 | SLC1A3 (0.35) | ALDH1A1CYP3A4MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0489877-B1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES | UPJOHN CO (US) | 1995-09-20 | — | — | EP | disclosed |
| US-5302613-A | Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones | THE UPJOHN COMPANY (US) | 1994-04-12 | — | — | US | disclosed |
| US-5252735-A | Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones | THE UPJOHN COMPANY (US) | 1993-10-12 | — | — | US | disclosed |
| EP-0489877-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES. | UPJOHN CO (US) | 1992-06-17 | — | — | EP | disclosed |
| WO-1992000290-A1 | ANTIATHEROSCLEROTIC AND ANTITHROMBOTIC 2-AMINO-6-PHENYL-4H-PYRAN-4-ONES | THE UPJOHN COMPANY (US) | 1992-01-09 | — | — | WO | disclosed |