Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 10/20 | 0.58 |
| ▸ | HTR3E | A5X5Y0 | 7/20 | 0.58 |
| ▸ | HTR3B | O95264 | 7/20 | 0.58 |
| ▸ | HTR3D | Q70Z44 | 7/20 | 0.58 |
| ▸ | HTR3C | Q8WXA8 | 7/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9429391 | 0.88 | HTR3A (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7284925 | 0.80 | MEN1 (0.46) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9199909 | 0.80 | HTR3E (0.61) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL7435030 | 0.80 | HTR3A (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL5248712 | 0.74 | ALDH1A1 (0.57) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL5250711 | 0.74 | ALDH1A1 (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL9059703 | 0.74 | CHRNA7 (0.53) | HTR3A | |
| SCHEMBL13186221 | 0.73 | HTR3A (0.85) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL3533984 | 0.73 | GAA (0.68) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| SCHEMBL29406314 | 0.73 | HTR3A (0.63) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0564650-B1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1995-09-20 | — | — | EP | claimed |
| US-5319085-A | Antiemetic agents; anticarcinogenic agent-induced vomiting; antianxiolytic agents; psychological disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-06-07 | — | — | US | claimed |
| EP-0564650-A1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-10-13 | — | — | EP | claimed |
| EP-0564650-B1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO KK (JP) | 1995-09-20 | — | — | EP | disclosed |
| US-5319085-A | Antiemetic agents; anticarcinogenic agent-induced vomiting; antianxiolytic agents; psychological disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1994-06-07 | — | — | US | disclosed |
| EP-0564650-A1 | QUINOLINE DERIVATIVE | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-10-13 | — | — | EP | disclosed |