SCHEMBL7830573

SCHEMBL7830573

c1ccc2c(c1)CCCC2COc1ncnc2nc[nH]c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK1 P06493 4/20 0.56
CDK2 P24941 4/20 0.56
CDC7 O00311 3/20 0.49
DBF4 Q9UBU7 3/20 0.49
LMNA P02545 4/20 0.41
PDPK1 O15530 1/20 0.41
METAP2 P50579 4/20 0.40
HSD17B10 Q99714 2/20 0.40
TSHR P16473 1/20 0.40
CCNB1 P14635 3/20 0.39
CCNA2 P20248 3/20 0.39
CCNA1 P78396 3/20 0.39
CCNB2 O95067 2/20 0.39
CCNB3 Q8WWL7 2/20 0.39
CLK1 P49759 2/20 0.38
HTT P42858 2/20 0.38
PKM P14618 1/20 0.38
ADRA2A P08913 1/20 0.38
ADRA1D P25100 1/20 0.38
ADRA1A P35348 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7834228 0.81 CDK1 (0.46) CDK1CDK2CDC7DBF4LMNA
SCHEMBL7835862 0.81 LMNA (0.41) CDK1CDK2CDC7DBF4LMNA
SCHEMBL7834591 0.79 CDC7 (0.50) CDC7DBF4LMNAHSD17B10TSHR
SCHEMBL7830410 0.78 CYP19A1 (0.40) ADRA2AADRA1DADRA1AADRA1BCYP19A1
SCHEMBL7831060 0.74 SIGMAR1 (0.38) CYP19A1TBXAS1SIGMAR1
SCHEMBL9199779 0.73 CDK2 (0.86) CDK1CDK2CDC7DBF4LMNA
SCHEMBL7830640 0.73 G6PD (0.46) CDC7DBF4LMNAHSD17B10TSHR
SCHEMBL6268103 0.72 CDK2 (1.00) CDK1CDK2CDC7DBF4LMNA
SCHEMBL7821333 0.70 HTR6 (0.41) CDK1CDK2PDPK1CCNB1CCNA2
Hydrochloric Acid SCHEMBL7822348 0.69 HTR6 (0.41) CDK1CDK2PDPK1CCNB1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0802914-B1 ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES PHARMACIA & UPJOHN SPA (IT) 2001-06-06 EP claimed
EP-0802914-A1 ARYL AND HETEROARYL PURINE COMPOUNDS PHARMACIA & UPJOHN S.p.A. (IT) 1997-10-29 EP claimed
WO-1997018212-A1 ARYL AND HETEROARYL PURINE COMPOUNDS PHARMACIA & UPJOHN S.P.A. (IT) 1997-05-22 WO claimed
EP-0802914-B1 ARYL- AND HETEROARYL- PURINE AND PYRIDOPYRIMIDINE DERIVATIVES PHARMACIA & UPJOHN SPA (IT) 2001-06-06 EP disclosed
US-5965563-A NOVEL PURINE DERIVATIVES SUCH AS N6-(2-OXINDOL-5-YL) ADENINE, METHODS OF SYNTHESIZING THEM; USE AS TYROSINE KINASE INHIBITORS PHARMACIA & UPJOHN S.P.A. (IT) 1999-10-12 US disclosed
EP-0802914-A1 ARYL AND HETEROARYL PURINE COMPOUNDS PHARMACIA & UPJOHN S.p.A. (IT) 1997-10-29 EP disclosed
WO-1997018212-A1 ARYL AND HETEROARYL PURINE COMPOUNDS PHARMACIA & UPJOHN S.P.A. (IT) 1997-05-22 WO disclosed