Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 10/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | HTR2C | P28335 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9198976 | 0.92 | AKR1B1 (0.78) | AKR1B1RECQLSLC6A4HTR2AHTR2C | |
| SCHEMBL9195206 | 0.88 | AKR1B1 (1.00) | AKR1B1 | |
| SCHEMBL9200165 | 0.79 | AKR1B1 (1.00) | AKR1B1SMN1; SMN2 | |
| SCHEMBL9277880 | 0.76 | ALDH1A1 (0.62) | AKR1B1RECQLSLC6A4HTR2AHTR2C | |
| SCHEMBL9197789 | 0.74 | RECQL (0.81) | AKR1B1RECQLSLC6A4ALDH1A1SMN1; SMN2 | |
| SCHEMBL9201748 | 0.74 | SLC6A4 (0.65) | AKR1B1RECQLSLC6A4HTR2AHTR2C | |
| SCHEMBL9328064 | 0.72 | RECQL (0.53) | AKR1B1RECQLSLC6A4HTR2AHTR2C | |
| SCHEMBL9200706 | 0.72 | AKR1B1 (0.73) | AKR1B1RECQLALDH1A1SMN1; SMN2CYP1A2 | |
| SCHEMBL8201334 | 0.72 | AKR1B1 (0.78) | AKR1B1 | |
| SCHEMBL24076901 | 0.71 | CYP2C9 (0.56) | AKR1B1RECQLSLC6A4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0436307-B1 | Substituted oxophthalazinyl acetic acids and analogs thereof | PFIZER (US) | 1995-02-22 | — | — | EP | disclosed |
| US-5304557-A | Aldose reductase inhibitor | PFIZER INC. (US) | 1994-04-19 | — | — | US | disclosed |