Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | AKR1B1 | P15121 | 9/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.44 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9327440 | 0.85 | SMN1; SMN2 (0.48) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL9277880 | 0.76 | ALDH1A1 (0.62) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL8201334 | 0.73 | AKR1B1 (0.78) | AKR1B1AKR1B10AKR1A1GLO1 | |
| SCHEMBL9198976 | 0.73 | AKR1B1 (0.78) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL9199872 | 0.72 | AKR1B1 (0.79) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL9201748 | 0.72 | SLC6A4 (0.65) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL5014224 | 0.71 | RECQL (0.83) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL9197789 | 0.70 | RECQL (0.81) | RECQLALDH1A1SLC6A4SMN1; SMN2AKR1B1 | |
| SCHEMBL5009469 | 0.70 | RECQL (0.81) | RECQLALDH1A1SLC6A4HTR2AHTR2C | |
| SCHEMBL9374155 | 0.69 | RECQL (0.76) | RECQLALDH1A1SLC6A4HTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5304557-A | Aldose reductase inhibitor | PFIZER INC. (US) | 1994-04-19 | — | — | US | disclosed |
| EP-0436307-A1 | Substituted oxophthalazinyl acetic acids and analogs thereof | PFIZER INC. (US) | 1991-07-10 | — | — | EP | disclosed |