Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 2/20 | 0.35 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9200417 | 0.88 | PTGS2 (0.47) | PTGS2KDM1A | |
| SCHEMBL9202536 | 0.87 | PTGS2 (0.60) | PTGS2PTGS1NR3C2KDM1A | |
| SCHEMBL9208173 | 0.86 | PTGS2 (0.47) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9203215 | 0.84 | PTGS2 (0.54) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9207743 | 0.83 | PTGS2 (0.46) | PTGS2PTGS1NR3C2KDM1AMALT1 | |
| SCHEMBL9740973 | 0.80 | PTGS2 (0.65) | PTGS2PTGS1ALOX5 | |
| SCHEMBL9210820 | 0.80 | PTGS2 (0.47) | PTGS2PTGS1 | |
| SCHEMBL9201792 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1NR3C2KDM1A | |
| SCHEMBL9209095 | 0.80 | PTGS2 (0.63) | PTGS2PTGS1NR3C2KDM1A | |
| SCHEMBL9207608 | 0.80 | MALT1 (0.46) | PTGS2PTGS1KDM1AMALT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |