Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9202536 | 0.90 | PTGS2 (0.60) | PTGS2KDM1A | |
| SCHEMBL9208173 | 0.89 | PTGS2 (0.47) | PTGS2 | |
| SCHEMBL9200341 | 0.88 | PTGS2 (0.45) | PTGS2KDM1A | |
| SCHEMBL9203215 | 0.87 | PTGS2 (0.54) | PTGS2 | |
| SCHEMBL9207743 | 0.86 | PTGS2 (0.46) | PTGS2KDM1A | |
| SCHEMBL27351925 | 0.79 | SMN1; SMN2 (0.67) | PPP1CASMN1; SMN2 | |
| SCHEMBL9207383 | 0.78 | SMN1; SMN2 (0.53) | PTGS2KDM1APPP1CASMN1; SMN2 | |
| SCHEMBL9200424 | 0.77 | PTGS2 (0.48) | PTGS2 | |
| SCHEMBL9203630 | 0.77 | PTGS2 (0.65) | PTGS2 | |
| SCHEMBL6350193 | 0.76 | PTGS2 (0.78) | PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1046506-C | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1999-11-17 | — | — | CN | disclosed |
| EP-0418845-B1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO (JP) | 1995-08-09 | — | — | EP | disclosed |
| US-5134142-A | PYRAZOLE DERIVATIVES, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-07-28 | — | — | US | disclosed |
| EP-0418845-A1 | Pyrazole derivatives, processes for preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1991-03-27 | — | — | EP | disclosed |