Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.72 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
| ▸ | HRH2 | P25021 | 12/20 | 0.67 |
| ▸ | HRH1 | P35367 | 12/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9199244 | 0.94 | KCNH2 (0.63) | HRH3KCNH2HRH2HRH1ALDH1A1 | |
| SCHEMBL4224568 | 0.87 | HRH3 (0.93) | HRH3KCNH2HRH2HRH1ALDH1A1 | |
| SCHEMBL5214308 | 0.85 | HRH3 (0.72) | HRH3KCNH2HRH2HRH1ALDH1A1 | |
| SCHEMBL7250762 | 0.84 | KDM4E (0.70) | HRH3HRH2HRH1MEN1ALDH1A1 | |
| SCHEMBL4096430 | 0.84 | HRH3 (1.00) | HRH3KCNH2HRH2HRH1ALDH1A1 | |
| SCHEMBL10899499 | 0.84 | KCNH2 (0.57) | HRH3KCNH2HRH2HRH1 | |
| Hydrochloric Acid SCHEMBL10900765 | 0.82 | KCNH2 (0.56) | HRH3KCNH2HRH2HRH1 | |
| SCHEMBL21408538 | 0.82 | HRH3 (0.79) | HRH3KCNH2HRH2HRH1MEN1 | |
| SCHEMBL13765617 | 0.81 | HRH2 (0.59) | HRH3KCNH2HRH2HRH1MEN1 | |
| SCHEMBL13044318 | 0.81 | HRH2 (0.59) | HRH3KCNH2HRH2HRH1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1037268-C | Antipicornaviral pyridazinamines | JANSSEM PHARMACEUTICA N V (BE) | 1998-02-04 | — | — | CN | disclosed |
| EP-0435381-B1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA NV (BE) | 1995-11-02 | — | — | EP | disclosed |
| EP-0398425-B1 | Antirhinoviral piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers | JANSSEN PHARMACEUTICA NV (BE) | 1994-03-16 | — | — | EP | disclosed |
| US-5196535-A | Viricides | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-23 | — | — | US | disclosed |
| US-5100893-A | Viricides, effective against picorna virus, durability | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-03-31 | — | — | US | disclosed |
| EP-0435381-A1 | Antipicornaviral pyridazinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-07-03 | — | — | EP | disclosed |
| EP-0398425-A1 | Antirhinoviral piperidinyl, pyrrolidinyl and piperazinyl alkylphenol ethers | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-11-22 | — | — | EP | disclosed |