Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28161959 | 0.83 | HRH3 (0.60) | HRH3HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9202092 | 0.82 | HRH3 (0.50) | HRH3HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9873444 | 0.81 | ALDH1A1 (0.49) | LMNAMAPTHTR1A | |
| SCHEMBL611154 | 0.81 | PLD1 (0.59) | LMNAMAPT | |
| SCHEMBL9201106 | 0.81 | HTR1A (0.56) | HRH3HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9203045 | 0.81 | HTR1A (0.56) | HRH3HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL3879984 | 0.81 | HTR1A (0.56) | HRH3HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL28173370 | 0.78 | HRH3 (0.57) | HRH3 | |
| SCHEMBL19823057 | 0.78 | HTR1A (0.70) | HTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL3882641 | 0.78 | HTR1A (0.51) | MAPTHRH3HTR1AADRA1DADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431580-B1 | Substituted cyclohexanols as central nervous system agents | WARNER LAMBERT CO (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0431579-B1 | Substituted cyclohexenes as central nervous system agents | WARNER LAMBERT CO (US) | 1994-07-27 | — | — | EP | disclosed |
| US-5047406-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT CO. (US) | 1991-09-10 | — | — | US | disclosed |
| EP-0431580-A2 | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| EP-0431579-A2 | Substituted cyclohexenes as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1991-06-12 | — | — | EP | disclosed |
| US-4988699-A | Treatment of psychological disorders such as schizophrenia, as antipsychotic agents and hypotensive agents | WARNER-LAMBERT COMPANY (US) | 1991-01-29 | — | — | US | disclosed |
| US-4975445-A | Antidepressants | WARNER-LAMBERT COMPANY (US) | 1990-12-04 | — | — | US | disclosed |
| US-4957921-A | Substituted cyclohexanols as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1990-09-18 | — | — | US | disclosed |