Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 7/20 | 0.82 |
| ▸ | ADRA1D | P25100 | 6/20 | 0.82 |
| ▸ | ADRA1B | P35368 | 6/20 | 0.82 |
| ▸ | HTR1A | P08908 | 5/20 | 0.52 |
| ▸ | DRD2 | P14416 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 2/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9194060 | 0.93 | ADRA1A (0.89) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| Hydrochloric Acid SCHEMBL9316958 | 0.92 | ADRA1A (0.88) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9274801 | 0.92 | ADRA1A (0.79) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9195487 | 0.91 | ADRA1A (0.80) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL5597266 | 0.90 | ADRA1D (1.00) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9316801 | 0.89 | ADRA1D (0.75) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9317007 | 0.88 | ADRA1D (0.87) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9193925 | 0.88 | ADRA1D (0.87) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9195313 | 0.88 | ADRA1A (0.62) | ADRA1AADRA1DADRA1BHTR1ADRD2 | |
| SCHEMBL9468889 | 0.88 | ADRA1A (0.75) | ADRA1AADRA1DADRA1BHTR1ADRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0577470-B1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1995-05-24 | — | — | EP | disclosed |
| US-5330985-A | Adrenergic blocking agents; urogenital disorders | SYNTHELABO (FR) | 1994-07-19 | — | — | US | disclosed |
| EP-0577470-A1 | 2-Amino-N-[[[4-(aminocarbonyl)pyrimidin-2-yl]amino]alkyl]-pyrimidine-4-carboxamide derivates, their preparation and their use in therapeutics | SYNTHELABO (FR) | 1994-01-05 | — | — | EP | disclosed |