Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.76 |
| ▸ | RAB9A | P51151 | 1/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 4/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SGMS2 | Q8NHU3 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 1/20 | 0.49 |
| ▸ | VEGFA | P15692 | 1/20 | 0.48 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5741190 | 0.92 | NPC1 (0.62) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL4452726 | 0.82 | NPC1 (0.52) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL621853 | 0.81 | NPC1 (0.51) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL8874717 | 0.81 | SQOR (0.57) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL646003 | 0.81 | NPC1 (0.51) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL4739158 | 0.80 | RAB9A (0.59) | NPC1RAB9AMAPTMAPK1L3MBTL1 | |
| SCHEMBL13485291 | 0.80 | NPC1 (0.60) | NPC1RAB9AMAPTALDH1A1KDM4E | |
| SCHEMBL3918899 | 0.79 | NPC1 (0.50) | NPC1RAB9AMAPTMAPK1TDP1 | |
| SCHEMBL16098128 | 0.79 | RAB9A (0.55) | NPC1RAB9AMAPTMAPK1L3MBTL1 | |
| SCHEMBL421736 | 0.79 | NPC1 (0.50) | NPC1RAB9AMAPTHTR1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0687249-A1 | BALANOIDS | ELI LILLY AND COMPANY (US) | 1995-12-20 | — | — | EP | disclosed |
| WO-1994020062-A2 | BALANOIDS AS PROTEIN KINASE C INHIBITORS | ELI LILLY AND COMPANY (US) | 1994-09-15 | — | — | WO | disclosed |